Dogs and humans may share some of the same biological patterns that are linked to lifespan, according to new research from the Dog Aging Project.
Researchers found that metabolite patterns tied to both earlier and later deaths in dogs showed a close resemblance to those previously seen in humans. The findings could help them better understand aging in both species.
"The molecules that are risky for dogs or protective against a sooner death are very similar to those in people, showing that we share important features of aging biology, which is really interesting and rewarding," said Dr. Kate Creevy, the chief veterinary officer for the Dog Aging Project and a professor at the Texas A&M College of Veterinary Medicine and Biomedical Sciences.
The research team analyzed blood samples from dogs participating in the Dog Aging Project, which is a community science effort that involves tracking dogs throughout their lives. Dog owners provide detailed survey responses and even physical samples in some cases.
The researchers examined the blood samples for metabolic patterns connected to lifespan, paying close attention to whether dogs died earlier or later.
They looked at which biological processes may have led to the deaths. These processes can include inflammation, metabolism, and the way cells react to stress.
The team also studied thousands of metabolites to search for larger patterns associated with risk. Looking at groups of metabolites instead of individual molecules can reveal a clearer picture of what is happening inside cells.
"Some of my colleagues refer to it as a fingerprint," said Creevy. "We often look at a pattern or grouping that has a relationship with better or worse outcomes rather than just looking at a single molecule."
Then, the researchers can predict how likely certain health outcomes are to occur. Furthermore, they can start exploring aging processes and eventually determine what biological aspects might help improve health.

They compared their results with five major published studies about human mortality and found that human signals related to earlier or later death were similar to those in dogs.
Dogs live closely with humans. This overlap creates a window of opportunity for scientists to observe how lifestyle and environment affect health over time.
"One of the things we like most about learning from dogs as it pertains to aging is their widely varied lifestyles that mirror their owners' lifestyles in a way that's less true for other companion animals," said Creevy.
For instance, cats tend to be more independent and are often doing their own thing, while dogs are more likely to follow their owners' daily habits and routines.
Additionally, dogs age much faster than humans, allowing researchers to study their lifespan and aging more quickly than with humans.
Overall, the findings were published in The Journals of Gerontology.































